Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

51-21-8 - 5-Fluorouracil, 99% - 5-Fluoro-2,4(1H,3H)-pyrimidinedione - 5-FU - A13456 - Alfa Aesar

A13456 5-Fluorouracil, 99%

CAS-Nummer
51-21-8
Synonyme
5-Fluoro-2,4(1H,3H)-pyrimidinedione
5-FU

Größe Preis ($) Menge Verfügbarkeit
5g 69,73
25g 283,25
100g 953,78
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

5-Fluorouracil, 99%

MDL
MFCD00006018
EINECS
200-085-6

Chemische Eigenschaften

Formel
C4H3FN2O2
Molmasse
130.08
Schmelzpunkt
ca 282° dec.
Sensitivität
Light Sensitive
Löslichkeit
Soluble in dimethylformamide, dimethyl sulfoxide, methanol, hot water, ammonium hydroxide, sodium hydroxide, ethanol and water.

Anwendungen

5-Fluorouracil is used as an antitumor agent in the treatment of anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers. It finds application as a suicide inhibitor due to its irreversible inhibition of thymidylate synthase. It is also used in the treatment of actinic keratoses and bowen's disease. Further, it serves as a potent antineoplastic agent in clinical use. In addition to this, it acts as a DNA synthesis inhibitor.

Bemerkungen

Store in a cool place. Incompatible with strong oxidizing agents and strong bases.

Literaturverweise

Antineoplastic agent. Not for drug use.

Cosco, D.; Paolino, D.; Maiuolo, J.; Di Marzio, L.; Carafa, M.; Ventura, C. A.; Fresta, M. Ultradeformable liposomes as multidrug carrier of resveratrol and 5-fluorouracil for their topical delivery. Int. J. Pharm. 2015, 489 (1-2), 1-10.

Wu, X.; He, C.; Wu, Y.; Chen, X. Synergistic therapeutic effects of Schiff's base cross-linked injectable hydrogels for local co-delivery of metformin and 5-fluorouracil in a mouse colon carcinoma model. Biomaterials 2016, 75, 148-162.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H360-H341-H373-H302

May damage fertility or the unborn child. Suspected of causing genetic defects. May cause damage to organs through prolonged or repeated exposure. Harmful if swallowed.

Sicherheitshinweise: P260-P201-P281-P264-P270-P301+P312-P308+P313-P314-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF exposed or concerned: Get medical advice/attention. Get medical advice/attention if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,4181
Beilstein
127172
Gefahrenklasse
6.1
Verpackungsgruppe
III
Harmonized Tariff Code
2933.59
TSCA
Yes
RTECS
YR0350000

Empfohlen

Kürzlich angesehen

Chemikalien

Life science

Metalle und Stoffe

Katalysatoren

Forschungs- und Laborbedarf