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L-Aspartic acid is used in enzyme active centers, as well as in maintaining the solubility and ionic character of proteins.
Flaig, R.; Koritsanszky, T.; Zobel, D.; Luger, P. Topological Analysis of the Experimental Electron Densities of Amino Acids. 1. d,l-Aspartic Acid at 20 K. J. Am. Chem. Soc. 1998, 120, (10), 2227-2238.
Xiao-Lin Wang.; Ai-Ling Ying.; Wei-Ning Wang. Nanofiltration of l-phenylalanine and l-aspartic acid aqueous solutions. Journal of Membrane Science. 2002, 196, (1), 59-67.
Readily forms ß-lactam derivatives whichare valuable intermediates for the synthesis of a variety of products, including thienamycin: J. Am. Chem. Soc., 102, 6163 (1980); Tetrahedron Lett., 23, 2293 (1982).