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421-50-1 - 1,1,1-Trifluoroacetone, 95% - 1,1,1-Trifluoro-2-propanone - A13556 - Alfa Aesar

A13556 1,1,1-Trifluoroacetone, 95%

CAS-Nummer
421-50-1
Synonyme
1,1,1-Trifluoro-2-propanone

Größe Preis ($) Menge Verfügbarkeit
25g 84,78
100g 201,20
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1,1,1-Trifluoroacetone, 95%

MDL
MFCD00000423
EINECS
207-005-9

Chemische Eigenschaften

Formel
CF3COCH3
Molmasse
112.05
Schmelzpunkt
<-78°
Siedepunkt
21-24°
Flammpunkt
-31°(-24°F)
Dichte
1.252
Brechungsindex
1.3000
Löslichkeit
Insoluble in water.

Anwendungen

1,1,1-Trifluoroacetone is used in a synthesis of 2-trifluoromethyl-7-azaindoles starting with 2,6-dihalopyridines. The derived chiral imine was used to prepare enantiopure &#945;-trifluoromethyl alanines and diamines via a Strecker reaction followed by either nitrile hydrolysis or reduction. And also used as a useful molecule in synthesis reactions.

Bemerkungen

Air Sensitive. Store in cool, dry conditions in well sealed containers. Keep container tightly closed.

Literaturverweise

Gandini, A.; Hackett, P.A. Electronic relaxation processes in acetone and 1,1,1-trifluoroacetone vapor and the gas phase recombination of the acetyl radical at 22.degree.C. J. Am. Chem. Soc. 1977, 99, (19), 6195-6205.

Jonathan O. Smith.; Braja K. Mandal.; Robert Filler.; James W. Beery. Reaction of ethyl 4,4,4-trifluoroacetoacetate enolate with 3-bromo-1,1,1-trifluoroacetone: synthesis of 2,4-bis (trifluoromethyl) furan. Journal of Fluorine Chemistry. 1977, 81, (2), 123-128.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H224-H315-H319-H335

Extremely flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P210-P261-P280-P240-P303+P361+P353-P305+P351+P338-P304+P340-P362-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
1748614
Gefahrenklasse
3
Verpackungsgruppe
I
Harmonized Tariff Code
2914.70
TSCA
Yes

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