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105-45-3 - Methyl acetoacetate, 99% - Acetoacetic acid methyl ester - A13696 - Alfa Aesar

A13696 Methyl acetoacetate, 99%

CAS-Nummer
105-45-3
Synonyme
Acetoacetic acid methyl ester

Größe Preis ($) Menge Verfügbarkeit
250g 14,40
1000g 33,12
5000g 126,00
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Methyl acetoacetate, 99%

MDL
MFCD00008784
EINECS
203-299-8

Chemische Eigenschaften

Formel
C5H8O3
Molmasse
116.12
Schmelzpunkt
-80°
Siedepunkt
170°
Flammpunkt
70°(158°F)
Dichte
1.076
Brechungsindex
1.4185
Löslichkeit
Soluble in water

Anwendungen

Methyl acetoacetate is used as a chemical reagent used in the synthesis of pharmaceuticals. It participates in the Biginelli reaction, forming molecules including dihydropyrimidinones.Methyl acetoacetate (MAA) is used for the synthesis of alpha-substituted aceto- acetic esters and cyclic compounds, e.g. pyrazole, pyrimidine and coumarin derivatives.

Bemerkungen

Store at 2-8°C. Incompatible with oxidizing agents and bases. Protect from light.

Literaturverweise

Michael M. Folkendt; Boris E. Weiss-Lopez; J. Paul ChauvelJr; Nancy S. True. Gas-phase proton NMR studies of keto-enol tautomerism of acetylacetone, methyl acetoacetate, and ethyl acetoacetate.J. Phys. Chem.1985, 89 (15), 3347-3352.

Mark A. Keane; Geoffrey Webb. The enantioselective hydrogenation of methyl acetoacetate over supported nickel catalysts: I. The modification procedure.Journal of Catalysis.1992, 136 1-15.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H319-H227

Causes serious eye irritation. Combustible liquid.

Sicherheitshinweise: P210-P280-P264-P305+P351+P338-P337+P313-P370+P378a-P403+P235-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. In case of fire: Use for extinction: CO2, powder or water spray. Store in a well-ventilated place. Keep cool. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,6009
Beilstein
506727
Harmonized Tariff Code
2918.30
TSCA
Yes
RTECS
AK5775000

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