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366-77-8 - 3-(4-Fluorobenzoyl)propionic acid, 97% - A13755 - Alfa Aesar

A13755 3-(4-Fluorobenzoyl)propionic acid, 97%

CAS-Nummer
366-77-8
Synonyme

Größe Preis ($) Menge Verfügbarkeit
5g 19,52
25g 82,80
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3-(4-Fluorobenzoyl)propionic acid, 97%

MDL
MFCD00002793
EINECS
206-679-1

Chemische Eigenschaften

Formel
C10H9FO3
Molmasse
196.18
Schmelzpunkt
99-103°
Löslichkeit
Insoluble in water.

Anwendungen

7-Fluoro-1-tetralone was prepared from 3-(4-fluorobenzoyl)-propionic acid by Wolff-Kishner reduction followed by ring closure with polyphosphoric acid and other substituted 1-tetralones where commercially available. Reduction of 3-(4-fluorobenzoyl)propionic acid with an excess of tert-butylamine borane (TBAB) in the presence of AlCl3 provided 4-(4-fluorophenyl)-1-butanol (87) in 63% yield for the synthesis of LM-1507 sodium salt. Penfluridol 1-[4,4-bis(4-fluorophenyl)butyl]-4-(4-chloro-3-trifluoromethylphenyl)- 4-hydroxypiperidine, C 28 H 27 ClF 5 NO, M r 523.99, mp 105 - 107°C, is obtained by reducing the ketone of 3-(4-fluorobenzoyl)propionic acid into a lactone.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literaturverweise

Lodewyk J. Mienie,; Jacobus J. Bergh,; Jeffrey R. Bloomquist,; Neal Castagnoli Jr.,; Stefanus J. Steyn,; Cornelis J. Van der Schyf. p-Fluorophenylglycine in the urine of baboons treated with HPTP, the tetrahydropyridine analog of haloperidol. Life Sciences. 1999, 65 (5), 535-542.

Hyeon Soo Kim,; Minseok Song,; Sanatombi Yumkham,; Jang Hyun Choi,; Taehoon Lee,; Joseph Kwon,; Sung Jae Lee. Identification of a new functional target of haloperidol metabolite: implications for a receptor-independent role of 3-(4-fluorobenzoyl) propionic acid. Journal of Neurochemistry. 2006, 99(2), 458-469.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P280g-P305+P351+P338

Wear protective gloves. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Weitere Referenzen

Beilstein
958145
Harmonized Tariff Code
2918.30
TSCA
No

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