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363-72-4 - Pentafluorobenzene, 98+% - A13948 - Alfa Aesar

A13948 Pentafluorobenzene, 98+%

CAS-Nummer
363-72-4
Synonyme

Größe Preis ($) Menge Verfügbarkeit
5g 19,16
25g 67,47
100g 225,57
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

Pentafluorobenzene, 98+%

MDL
MFCD00000286
EINECS
206-658-7

Chemische Eigenschaften

Formel
C6HF5
Molmasse
168.06
Schmelzpunkt
-48°
Siedepunkt
84-85°
Flammpunkt
13°(55°F)
Dichte
1.518
Brechungsindex
1.3910
Löslichkeit
Insoluble in water.

Anwendungen

Pentafluorobenzene is a fluorinated benzene with anesthetic properties. Pentafluorobenzene has been shown to potently and reversibly inhibited human α4β2 neuronal nicotinic acetylcholine receptor depe ndent on drug hydrophobicity in Xenopus laevis oocyte. New reaction conditions are described that enable the direct arylation of pentafluorobenzene with sterically encumbered aryl bromides and aryl chlorides. Bis (pentafluoropheny1) methane and tris (pentafluoropheny1) methane were prepared in 77 and 92% yields, respectively, by a Friedel-Crafts reaction of pentafluorobenzene with methylene chloride and chloroform using aluminum chloride as the Lewis acid.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literaturverweise

W. F. Beckert,; James U. LoweJr.. Friedel-Crafts alkylation of pentafluorobenzene. J. Org. Chem.,. 1967, 32 (4),1212-1215.

Marc Lafrance,; Daniel Shore,; Keith Fagnou. Mild and General Conditions for the Cross-Coupling of Aryl Halides with Pentafluorobenzene and Other Perfluoroaromatics. Org. Lett. 2006, 8(26) ,5097-5100.

Used for the introduction of the pentafluorophenyl group via pentafluorophenyllithium, stable at low temperatures. Review of the effects of the pentafluorophenyl group on reactivity: Fluorine Chem. Rev., 8, 1 (1977).

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H225-H302

Highly flammable liquid and vapour. Harmful if swallowed.

Sicherheitshinweise: P210-P280-P240-P241-P233-P242-P303+P361+P353-P301+P312-P403+P235-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Keep container tightly closed. Use only non-sparking tools. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store in a well-ventilated place. Keep cool. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
1911549
Gefahrenklasse
3
Verpackungsgruppe
III
Harmonized Tariff Code
2903.99
TSCA
Yes
RTECS
DA6651600

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