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3,3-Dimethyl-1-butyne is used as an active pharmaceutical intermediate for terbinafine. It is also used in the preparation of 2,2,7,7-tetramethyl-octa-3,5-diyne. Further, it is used in the synthesis of erythro and threo isomers of B-(3,3-dimethyl-1,2-dideuterio-1-butyl)-9-BBN by hydroboration-deuteronolysis-hydroboration sequence.
1-Alkynes react with Schwartz's reagent, (Bis(cyclopentadienyl)zirconium hydridochloride, L15164), to give vinyl zirconium complexes, which undergo conjugate addition to enones in the presence of a nickel catalyst: J. Am. Chem. Soc., 99, 8045 (1977):
Gao, P.; Wang, Z.; Wang, X.; Zhang, W.; Gao, Z. Linear and V-Shaped Alkynyl-1,3,5-triazines. Eur. J. Org. Chem. 2015, 2015 (32), 7020-7027.
Liu, D.; Qiu, Z.; Xie, Z. Synthesis, structure, and alkyne insertion of a mixed-sandwich zirconacarborane alkyl. Inorg. Chem. Front. 2015, 2 (5), 467-472.
Gefahrenhinweise (EU): H225-H304
Highly flammable liquid and vapour. May be fatal if swallowed and enters airways.
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid release to the environment. Keep container tightly closed. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Get immediate medical advice/attention. Store in a well-ventilated place. Keep cool.