Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

534-07-6 - 1,3-Dichloroacetone, 96% - 1,3-Dichloro-2-propanone - A14149 - Alfa Aesar

A14149 1,3-Dichloroacetone, 96%

CAS-Nummer
534-07-6
Synonyme
1,3-Dichloro-2-propanone

Größe Preis ($) Menge Verfügbarkeit
25g 34,30
100g 129,78
500g 396,00
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

1,3-Dichloroacetone, 96%

MDL
MFCD00000937
EINECS
208-585-6

Chemische Eigenschaften

Formel
C3H4Cl2O
Molmasse
126.97
Schmelzpunkt
40-44°
Siedepunkt
172-173°
Flammpunkt
95°(203°F)
Dichte
1.383
Brechungsindex
1.4400
Löslichkeit
Soluble in water, ethanol and diethyl ether.

Anwendungen

1,3-Dichloroacetone is used in the synthesis of citric acid. It is used as a solvent and as an intermediate in organic synthesis. Further, it serves as an acceptor substrate in the cross-aldol reaction with donor substrates such as acetone, cyclopentanone and cyclohexanone. It is also used in the preparation of an active pharmaceutical ingredient, famotidine.

Bemerkungen

Hygroscopic. Store in a cool place. Incompatible with strong oxidizing agents, strong bases and reducing agents.

Literaturverweise

Successive reaction with a Grignard reagent and Li metal leads to 1-substituted cyclopropanols, which rearrange on thermolysis to ethyl ketones: Synthesis, 647 (1983):

The cyclization can also be induced by ethyl radicals, generated from ethylmagnesium bromide and FeCl3. This method is applicable only to 1-arylcyclopropanols: J. Org. Chem., 29, 2813 (1964); 43, 3602 (1978); Org. Synth. Coll., 5, 1058 (1973).

Formation of the acetal followed by treatment with NaNH2 provides a route to cyclopropenones: Tetrahedron, 48, 2045 (1992).

Serrano, M.; Silva, M.; Gallego, M. Determination of 14 haloketones in treated water using solid-phase microextraction and gas chromatography-mass spectrometry. J. Chromatogr. A 2015, 1407, 208-215.

Deng, J.; Chen, K.; Yao, Z.; Lin, J.; Wei, D. Efficient synthesis of optically active halogenated aryl alcohols at high substrate load using a recombinant carbonyl reductase from Gluconobacter oxydans. J. Mol. Catal. B: Enzym. 2015, 118, 1-7.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H300-H310-H330-H314-H318-H341-H400-H410

Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage. Suspected of causing genetic defects. Very toxic to aquatic life. Very toxic to aquatic life with long lasting effects.

Sicherheitshinweise: P273-P280-P305+P351+P338-P309-P310-P302+P352-P501a

Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,3052
Beilstein
605456
Gefahrenklasse
6.1
Verpackungsgruppe
II
Harmonized Tariff Code
2914.70
TSCA
Yes
RTECS
UC1430000

Empfohlen

Kürzlich angesehen

Chemikalien

Life science

Metalle und Stoffe

Katalysatoren

Forschungs- und Laborbedarf