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1H-Pyrazole is used as a ligand in the preparation of organometallic compounds. The derivatives of Pyrazole are used in medicine, for their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, tranquilizing, muscle relaxing, psychoanaleptic, anticonvulsant, monoamineoxidase inhibiting, antidiabetic and antibacterial activities.
Michael S. Bernatowicz; Youling Wu; Gary R. Matsueda. 1H-Pyrazole-1-carboxamidine hydrochloride an attractive reagent for guanylation of amines and its application to peptide synthesis. J. Org. Chem. 1992, 57 (8), 2497-2502.
Adnan A. Bekhit; Hayam M.A. Ashour; Yasser S. Abdel Ghany; Alaa El-Din A. Bekhit; Azza Baraka. Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents. European Journal of Medicinal Chemistry. 2008, 43 (3), 456-463.
Forms a complex with Pyridinium chlorochromate, A11752, which allows the selective oxidation of allylic alcohols in the presence of non-allylic alcohols: Lipids, 19, 550 (1984).
Can be protected on nitrogen by hydroxymethylation with paraformaldehyde, permitting 3-lithiation with t-BuLi: Tetrahedron, 45, 4253 (1989).
Gefahrenhinweise (EU): H302-H315-H319-H361-H335
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. Suspected of damaging fertility or the unborn child. May cause respiratory irritation.
Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.