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1,4-Dioxane is used as a stabilizer for 1,1,1-trichloroethane and chlorinated solvents. It acts as a solvent for cellulose acetate, ethyl cellulose, benzyl cellulose, resins, oils, waxes, dyes, other organic and inorganic compounds. It acts as a substitute for tetrahydrofuran due to its higher boiling point and lower toxicity. Further, it is used as an internal standard for proton NMR spectroscopy in deuterium oxide. It plays an important role in liquid scintillation counting in biological procedures, and as a wetting and dispersing agent in textile processing. It is involved in the preparation of dimethylmagnesium by reacting with methylmagnesium bromide, and in the preparation of histological sections for microscopic examination.
Adamson, D. T.; Anderson, R. H.; Mahendra, S.; Newell, C. J. Evidence of 1,4-Dioxane Attenuation at Groundwater Sites Contaminated with Chlorinated Solvents and 1,4-Dioxane. Environ. Sci. Technol. 2015, 49 (11), 6510-6518.
Rathi, P.; Jouyban, A.; Khoubnasabjafari, M.; Kale, M. Solubility of Etoricoxib in Aqueous Solutions of 1,4-Butanediol, 1,4-Dioxane, N,N-Dimethylacetamide, N,N-Dimethylformamide, Dimethyl Sulfoxide, and Ethanol at 298.2 K. J. Chem. Eng. Data 2015, 60 (7), 2128-2134.
Gefahrenhinweise (EU): H225-H319-H351-H335
Highly flammable liquid and vapour. Causes serious eye irritation. Suspected of causing cancer. May cause respiratory irritation.
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves and eye/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.