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499-80-9 - Pyridine-2,4-dicarboxylic acid, 98%, may cont. up to ca 10% water - Lutidinic acid - A14409 - Alfa Aesar

A14409 Pyridine-2,4-dicarboxylic acid, 98%, may cont. up to ca 10% water

CAS-Nummer
499-80-9
Synonyme
Lutidinic acid

Größe Preis ($) Menge Verfügbarkeit
5g 57,37
25g 188,80
100g 604,80
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

Pyridine-2,4-dicarboxylic acid, 98%, may cont. up to ca 10% water

MDL
MFCD00149413
EINECS
207-892-2

Chemische Eigenschaften

Formel
C7H5NO4
Molmasse
167.12
Schmelzpunkt
ca 245° dec.
Löslichkeit
Soluble in water at 20°C 4.5 g/L.

Anwendungen

It is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases. 2,4-Pyridinedicarboxylic acid has been used in a study to determine that ruthenium(II) complexes exert antimetastatic effects on several tumor cell lines in vitro, achieved mostly by the effect on cell adhesion, migration and angiogenesis. It blocks the activity of 2-OG oxygenases, which include certain lysine demethylases and a variety of hydroxylases (e.g., prolyl, collagen, lysyl). 2,3 2,4-PDCA inhibits several Jumonji domain-containing lysine demethylases when used at low micromolar concentrations. Through its effects on hydroxylases, including prolyl hydroxlase 1 (IC50 = 1.5 µM), It modulates hypoxia inducing factor turnover, collagen synthesis, and plant cell wall formation. It can inhibit zinc-dependent enzymes, like metallo-β-lactamase.8 2,4-PDCA also affects and is translocated by organic anion transporters.

Bemerkungen

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literaturverweise

Line H Kristensen, et al. Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor.FEBS J.,2012,279(11), 1905-1914.

Koski, M.K, et al.The active site of an algal prolyl 4-hydroxylase has a large structural plasticity. Biol Chem.,2007,282(51), 37112-37123.

Mackeen, et al. Small-molecule-based inhibition of histone demethylation in cells assessed by quantitative mass spectrometry. J Proteome Res.,2010,9(8), 4082-4092.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
131631
Harmonized Tariff Code
2933.39
TSCA
Yes

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