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Benzoylacetonitrile is used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is also used in the synthesis of substituted naphtho[1,8-bc]pyrans and as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.
L P Davies.; S C Chow.; J H Skerritt.; D J Brown.; G A Johnston. Pyrazolo[3,4-d]pyrimidines as adenosine antagonists.. Life Sciences. 1984, 34 (22), 2117-2128.
Tarek S. Mansour. Hunig's base-magnesium chloride mediated carbon alkylation and oxygen acylation of benzoylacetonitrile. Tetrahedron Letters. 1988, 29 (28), 3437-3440.
Active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines: Synthesis, 775 (1989). Reaction with tosic anhydride, followed by diethyl aminomalonate provides a short, facile synthesis of 3-aminopyrrole-2-carboxylates: J. Org. Chem., 65, 2603 (2000):
Gefahrenhinweise (EU): H301-H315-H319-H335
Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
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