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Wittig reaction (see Appendix 1) with aldehydes, using K2CO3 in toluene, gives dienes: Synth. Commun., 22, 1421 (1992). The derived phosphorane also reacts with ß-chloroacrylates to give conjugated phosphoranes, convertible to trienes: Tetrahedron Lett., 1359 (1975):/n
Michael addition of the phosphorane to ɑß-unsaturated ketones, followed by intramolecular Wittig reaction, gives cyclohexa-1,3-dienes: Tetrahedron Lett., 4425 (1973). Further lithiation of the phosphorane in the presence of TMEDA, followed by reaction of the ylide anion with an aldehyde, provides a route to (E,E)-ß-hydroxy-1,3-dienes: Tetrahedron Lett., 32, 4353 (1991)./n
Gefahrenhinweise (EU): H315-H319-H335
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