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Benzoylacetone has been used as a 1,3-dicarbonyl compound model for studying keto-enol equilibria in aqueous acid and micellar solutions. Additionally, it has been studied using gas-phase electron diffraction and quantum chemistry. It is used as pharmaceutical intermediates.
Maxwell L.Eidinoff. Dissociation constants of acetylacetone, ethyl acetoacetate and benzoylacetone. J. Am. Chem. Soc. 1945, 67, (12),2072-2073
Emilia Iglesias. Enolization of benzoylacetone in aqueous surfactant solutions:? A novel method for determining enolization constants. J. Phys. Chem. 1996, 100, (30),12592-12599
Dimetallated derivatives react with electrophiles preferentially at the terminal position; e.g. arylation by 2-chloroquinoline: J. Org. Chem., 37, 3199 (1972); J. Am. Chem. Soc., 97, 374 (1975). Reaction with aromatic esters gives 1,3-diaryl-1,3,5-pentanetriones, which can be cyclized with acid to -pyrones: Org. Synth. Coll., 5, 718, 721 (1973):