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543-27-1 - Isobutyl chloroformate, 98% - Chloroformic acid isobutyl ester - A14692 - Alfa Aesar

A14692 Isobutyl chloroformate, 98%

CAS-Nummer
543-27-1
Synonyme
Chloroformic acid isobutyl ester

Größe Preis ($) Menge Verfügbarkeit
25g 14,04
100g 26,64
500g 98,10
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Isobutyl chloroformate, 98%

MDL
MFCD00000642
EINECS
208-840-1

Chemische Eigenschaften

Formel
C5H9ClO2
Molmasse
136.58
Schmelzpunkt
-80°
Siedepunkt
128-129°
Flammpunkt
30°(86°F)
Dichte
1.048
Brechungsindex
1.4060
Sensitivität
Moisture Sensitive
Löslichkeit
Immiscible with water.

Anwendungen

Isobutyl chloroformate is used as a peptide reagent. It is also used in the preparation of phenethyl-carbamic acid isobutyl ester by reaction with phenethylamine.

Bemerkungen

Store in a cool place. Incompatible with strong oxidizing agents, acids, bases, alcohols and amines. Moisture sensitive.

Literaturverweise

Superior to ethyl chloroformate in the mixed anhydride method of peptide synthesis: Org. Prep. Proced. Int., 7, 215 (1975); review: Org. React., 12, 157 (1962). Use in combination with 1-Methyl­piperidine, L03398, minimizes competing urethane formation, arising from cleavage of the mixed anhydride in the wrong sense: J. Org. Chem., 48, 2939 (1983). Addition of CuCl2 is reported to suppress racemization completely: Chem. Lett., 2125 (1989). For peptide reagents, see Appendix 6.

Has been used to protect a nucleoside OH group as its isobutyl carbonate. Cleavage was by hydrolysis with 80% AcOH: J. Org. Chem., 32, 2365 (1967). Protection of amino groups as their isobutyl carbamates has also been reported: J. Am. Chem. Soc., 91, 3356 (1969).

Giráldez, I.; Ruiz-Azcona, P.; Vidal, A.; Morales, E. Speciation of selenite and selenoamino acids in biota samples by dual stir bar sorptive extraction-single desorption-capillary gas chromatography/mass spectrometry. Microchem. J. 2015, 122, 197-204.

Pan, X.; Dong, J.; Shao, R.; Su, P.; Shi, Y.; Wang, J.; He, L. Expanding the structural diversity of Bcr-Abl inhibitors: Hybrid molecules based on GNF-2 and Imatinib. Bioorg. Med. Chem. Lett. 2015, 25 (19), 4164-4168.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H300-H310-H330-H314-H318-H226

Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage. Flammable liquid and vapour.

Sicherheitshinweise: P210-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P320-P330-P361-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,5139
Beilstein
956590
Gefahrenklasse
6.1
Verpackungsgruppe
II
Harmonized Tariff Code
2915.90
TSCA
Yes

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