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3-(3,4-Methylenedioxyphenyl)propionic acid exhibits anti-inflammatory and analgesic activity. Further, it is used in the preparation of 3-benzo[1,3]dioxol-5-yl-propionyl chloride by reaction with thionyl chloride.
Conversion to the dianion and iodination gives the ɑ-iodo-derivative, a precursor of a wide range of lignans, in good yield: Synth. Commun., 18, 699 (1988).
Campaigne, E.; Kreighbaum, W. E. Substitution Reactions of 5,6-Dimethoxybenzothiophene and 5,6-Methylenedioxybenzothiophene. J. Org. Chem. 1961, 26 (2), 359-363.
Gefahrenhinweise (EU): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.