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5329-33-9 - O-Methylisourea hydrochloride, 98% - A14773 - Alfa Aesar

A14773 O-Methylisourea hydrochloride, 98%

CAS-Nummer
5329-33-9
Synonyme

Größe Preis ($) Menge Verfügbarkeit
10g 67,90
50g 299,00
250g 1263,00
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O-Methylisourea hydrochloride, 98%

MDL
MFCD00035043

Chemische Eigenschaften

Formel
C2H6N2O•HCl
Molmasse
110.54
Schmelzpunkt
ca 116° dec.
Löslichkeit
Soluble in organic solvents, water, methanol and ethanol.

Anwendungen

O-methylisourea hydrochloride is used to prepare 1-chloro-2-methyl-isourea. It is also used as an organic intermediate.

Bemerkungen

Incompatible with strong oxidizing agents.

Literaturverweise

Useful intermediate, more nucleophilic than urea itself, and avoiding toxicity of thiourea, in the synthesis of pyrimidines, by condensation with ß-diketones: Chem. Ber., 109, 3255 (1976); and of uracils, by condensation with ß-keto esters: Tetrahedron, 40, 3313 (1984); J. Heterocycl. Chem., 26, 883 (1989).

Reagent for guanylation of primary and secondary amines: Chem.-Ztg., 98, 617 (1974).

Reagent for selective methylation of SH groups at pH 8.5: Biochemistry, 9, 3343 (1970); 11, 110 (1972).

For a review of the synthetic applications of isoureas, see: Org. Prep. Proced. Int., 12, 309 (1980).

Paul, S.; Pattanayak, S.; Sinha, S. Synthesis and cell transfection properties of cationic uracil-morpholino tetramer. Tetrahedron Lett. 2014, 55 (5), 1072-1076.

Le?tinois, U.; Schu?tz, J.; Ha?rter, R.; Stoll, R.; Huffschmidt, F.; Bonrath, W.; Karge, R. Lewis acid-catalyzed synthesis of 4-aminopyrimidines: a scalable industrial process. Org. Process Res. Dev. 2013, 17 (3), 427-431.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
3909619
Harmonized Tariff Code
2924.19
TSCA
Yes

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