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22509-74-6 - N-(Ethoxycarbonyl)phthalimide, 97% - N-(Carbethoxy)phthalimide - Nefkens' Reagent - A14822 - Alfa Aesar

A14822 N-(Ethoxycarbonyl)phthalimide, 97%

CAS-Nummer
22509-74-6
Synonyme
N-(Carbethoxy)phthalimide
Nefkens' Reagent

Größe Preis ($) Menge Verfügbarkeit
25g 29,68
100g 113,40
500g 452,80
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N-(Ethoxycarbonyl)phthalimide, 97%

MDL
MFCD00005893
EINECS
245-048-5

Chemische Eigenschaften

Formel
C11H9NO4
Molmasse
219.20
Schmelzpunkt
78-84°
Löslichkeit
Insoluble in water.

Anwendungen

N-(Ethoxycarbonyl)phthalimide is used to protect amine functional groups. Reagent for the conversion of amines and amino acids to their phthaloyl derivatives under mild conditions

Bemerkungen

Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literaturverweise

Paul M. Worster.; Clifford C. Leznoff.; Colin R. McArthur. N-(Ethoxycarbonyl)phthalimide. An improved procedure. J. Org. Chem. 1980, 45, (1), 174-175.

M. Niyaz Khan. Suggested Improvement in the Ing-Manske Procedure and Gabriel Synthesis of Primary Amines:? Kinetic Study on Alkaline Hydrolysis of N-Phthaloylglycine and Acid Hydrolysis of N-(o-Carboxybenzoyl)glycine in Aqueous Organic Solvents. J. Org. Chem. 1980, 61, (23), 8063-8068.

Reagent for the conversion of amines and amino acids to their phthaloyl derivatives under mild conditions: Nature, 185, 309 (1960); J. Heterocycl. Chem., 29, 707 (1992). For improved procedures involving reaction of an aqueous solution of the Na salt of an amino acid with a solution of the reagent in ethyl acetate, see: Rec. Trav. Chim., 97, 260 (1978), or using triethylamine in THF giving excellent yields without racemization: Can. J. Chem., 60, 1836 (1982). See also Appendix 6.

Weitere Referenzen

Beilstein
196340
Harmonized Tariff Code
2925.19
TSCA
Yes
RTECS
NR3459500

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