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3034-53-5 - 2-Bromothiazole, 99% - A14838 - Alfa Aesar

A14838 2-Bromothiazole, 99%

CAS-Nummer
3034-53-5
Synonyme

Größe Preis ($) Menge Verfügbarkeit
10g 53,30
25g 129,00
50g 221,00
250g 942,00
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2-Bromothiazole, 99%

MDL
MFCD00005316
EINECS
221-229-4

Chemische Eigenschaften

Formel
C3H2BrNS
Molmasse
164.02
Siedepunkt
171°
Flammpunkt
63°(145°F)
Dichte
1.836
Brechungsindex
1.5930
Löslichkeit
It is insoluble in water.

Anwendungen

2-Bromothiazole, is intended used for research purpose only. It is also used as Aryl halide which are used to N-arylate 5- and 7-azaindoles. Copper-catalyzed cyanation provides 2-cyanothiazole

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from Strong oxidizing agents, Hydrogen bromide gas, nitrogen oxides (NOx), Sulphur oxides.

Literaturverweise

Henri Jean Marie Dou.; Roger Gallo.; Parina Hassanaly.; Jacques Metzger. Behavior and stability of catalysts in bi- and triphase transfer catalysis. J. Org. Chem . 1977, 42, (26), 4275-4276.

AO Pittet .; DE Hruza. Comparative study of flavor properties of thiazole derivatives. Journal of Agricultural and Food Chemistry. 1974, 22, (2), 264-269.

2-Lithiothiazole can be obtained by direct lithiation of thiazole or, more conveniently, by exchange with 2-bromothiazole using n-BuLi: J. Org. Chem., 53, 1748 (1988). It behaves as a valuable formyl anion equivalent, and as such has been applied, mainly by Dondoni's group, in the syntheses of a variety of products; see, e.g.: Tetrahedron Lett., 34, 7319, 7323, 7327 (1993). See also 2-(Trimethyl­silyl)­thiazole, B21903. Reaction of 2-lithiothiazole with nitrones gives ɑ-aminoaldehydes: Tetrahedron Lett., 33, 4221 (1992); stereocontrolled addition to C-galacto-pyranosylnitrone has been used in syntheses of destomic acid, a component of the antibiotics destomycin and hygromycin, and of lincosamine, the sugar component of the anticancer antibiotic lincomycin: Synlett, 78 (1993). For applications of 2-lithiothiazole in the synthesis of the aza-sugar (+)-galactostsin, see: J. Org. Chem., 60, 4749 (1995). The Thiazole Aldehyde Synthesis has been reviewed by Dondoni: Synthesis, 1681 (1998).

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H227-H315-H319-H335

Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P260u-P201-P280a-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves and eye/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
105724
Harmonized Tariff Code
2934.10
TSCA
Yes

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