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Formic acid hydrazide is used as a precursor in the preparation of 1,2,4-triazole derivatives. It is also used in the synthesis of 6-N-formylamino-12,13-dihydro-1,11-dihydroxy-13-(beta-D-glucopyranosyl)-5H-indolo[2,3-a]-pyrrolo[3,4-c]carbazole-5,7(6H)-dione, which is an anticancer agent.
Bokor, É.; Fekete, A.; Varga, G.; Sz?cs, B.; Czifrák, K.; Komáromi, I.; Somsák, L. C-(beta-D-Glucopyranosyl)formamidrazones, formic acid hydrazides and their transformations into 3-(beta-D-glucopyranosyl)-5-substituted-1,2,4-triazoles: a synthetic and computational study. Tetrahedron 2013, 69 (48), 10391-10404.
Guin, S.; Rout, S. K.; Gogoi, A.; Nandi, S.; Ghara, K. K.; Patel, B. K. Desulfurization Strategy in the Construction of Azoles Possessing Additional Nitrogen, Oxygen or Sulfur using a Copper(I) Catalyst. Adv. Synth. Catal. 2012, 354 (14-15), 2757-2770.
Gefahrenhinweise (EU): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.