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4637-24-5 - N,N-Dimethylformamide dimethyl acetal, 97% - 1,1-Dimethoxy-N,N-dimethylmethylamine - A15350 - Alfa Aesar

A15350 N,N-Dimethylformamide dimethyl acetal, 97%

CAS-Nummer
4637-24-5
Synonyme
1,1-Dimethoxy-N,N-dimethylmethylamine

Größe Preis ($) Menge Verfügbarkeit
25g 34,74
100g 98,26
500g 340,20
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N,N-Dimethylformamide dimethyl acetal, 97%

MDL
MFCD00008482
EINECS
225-063-3

Chemische Eigenschaften

Formel
(CH3)2NCH(OCH3)2
Molmasse
119.16
Schmelzpunkt
-85°
Siedepunkt
102-104°
Flammpunkt
7°(45°F)
Dichte
0.897
Brechungsindex
1.3972
Sensitivität
Moisture Sensitive
Löslichkeit
Miscible with most organic solvents.

Anwendungen

N,N-Dimethylformamide dimethyl acetal is used as an intermediate in the formation of pyridine derivatives, which exhibits inhibition against PI3 kinase p110alfa enzymes. It is utilized for the derivatization of primary sulfonamides and trifluoroacetic acid. It is also used in the preparation of formamidine derivatives. It is used as a reagent for n-dimethylaminomethylene and methyl esters. Further, it is used to catalyze the coupling of epoxides with carbon dioxide to prepare cyclic carbonates.

Bemerkungen

Moisture sensitive. Incompatible with strong oxidizing agents and acids.

Literaturverweise

Lee, H. J.; Lee, S.; Yu, J.; Kim, J. N. Vinylogous N,N-dimethylaminomethylenation of 3-[(1-substituted) ethylidene]-oxindoles with N,N-dimethylformamide dimethylacetal. Tetrahedron Lett. 2014, 55 (15), 2450-2454.

Prek, B.; Grošelj, U.; Kasunič, M.; Zupančič, S.; Svete, J.; Stanovnik, B. Reactions of Methyl Ketones and (Hetero)arylcarboxamides with N, N-Dimethylacetamide Dimethyl Acetal. A Simple Metal-Free Synthesis of 2, 4, 6-Trisubstituted Pyridines. Aust. J. Chem. 2015, 68 (2), 184-195.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H225-H302-H332-H315-H319-H335

Highly flammable liquid and vapour. Harmful if swallowed. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P210-P261-P280-P240-P303+P361+P353-P305+P351+P338-P304+P340-P362-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Gefahrenklasse
3
Verpackungsgruppe
II
Harmonized Tariff Code
2911.00
TSCA
Yes

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