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1622-32-8 - 2-Chloroethanesulfonyl chloride, 98% - 2-Chloroethylsulfonyl chloride - A15377 - Alfa Aesar

A15377 2-Chloroethanesulfonyl chloride, 98%

CAS-Nummer
1622-32-8
Synonyme
2-Chloroethylsulfonyl chloride

Größe Preis ($) Menge Verfügbarkeit
10g 42,54
50g 152,03
100g 255,69
250g 592,00
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2-Chloroethanesulfonyl chloride, 98%

MDL
MFCD00007461
EINECS
216-594-1

Chemische Eigenschaften

Formel
C2H4Cl2O2S
Molmasse
163.02
Siedepunkt
203°
Flammpunkt
>110°(230°F)
Dichte
1.560
Brechungsindex
1.4915
Sensitivität
Moisture Sensitive
Löslichkeit
Reacts with water.

Anwendungen

2-Chloroethanesulfonyl chloride was used in one-pot sulfonylation/intramolecular thia-Michael protocol for the synthesis of 1,5,2-dithiazepine 1,1-dioxides. It was also used in synthesis of vinyl sulfonamides with a furan, carbocyclic, semi cyclic or acyclic 1,3-diene moiety.

Bemerkungen

Moisture sensitive. Store under inert gas. Store away from moisture, oxidizing agents. Store in refrigerator.

Literaturverweise

James Frederick King; Kishan Chand Khemani. The mechanism of hydrolysis of 2-hydroxyethanesulfonyl chloride: the intermediacy of 1,2-oxathietane 2,2-dioxide (β-sultone). Canadian Journal of Chemistry. 1989, 67 (12), 2162-2172.

C. W. Huffman. Formylation of Amines. J. Org. Chem. 1958, 23 (5), 727-729.

In the presence of a base, converts alcohols to vinyl sulfonates: J. Am. Chem. Soc., 68, 1797 (1946); Angew. Chem. Int. Ed., 4, 300 (1965). These electrophilic alkenes readily undergo conjugate addition reactions with various nucleophiles:

Reaction with pentafluorophenol, in the presence of Et3N, gives PFP vinylsulfonate, which can be converted to a sulfonamide via tin-mediated radical addition of alkyl halides to the olefinic bond, followed by displacement of the PFP group with an amine: Org. Lett., 42549 (2002).

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H301-H330-H314-H318

Toxic if swallowed. Fatal if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage.

Sicherheitshinweise: P260-P284-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P320-P330-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
1751202
Gefahrenklasse
6.1
Verpackungsgruppe
I
Harmonized Tariff Code
2904.90
TSCA
Yes
RTECS
KI8060000

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