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305-01-1 - 6,7-Dihydroxycoumarin, 98+% - Cichorigenin - Esculetin - A15393 - Alfa Aesar

A15393 6,7-Dihydroxycoumarin, 98+%

CAS-Nummer
305-01-1
Synonyme
Cichorigenin
Esculetin

Größe Preis ($) Menge Verfügbarkeit
1g 48,20
5g 180,25
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6,7-Dihydroxycoumarin, 98+%

MDL
MFCD00006874
EINECS
206-161-5

Chemische Eigenschaften

Formel
C9H6O4
Molmasse
178.15
Schmelzpunkt
ca 270° dec.
Löslichkeit
Soluble in DMSO, DMF, diluted alkalies with blue fluorescence, and acetone. Slightly soluble in water. Insoluble in ether. Moderately soluble in Glacial acetic acid, and hot ethanol.

Anwendungen

In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agents.

Literaturverweise

Neichi Tomohiro; Koshihara Yasuko; Murota Sei-Itsu. Inhibitory effect of esculetin on 5-lipoxygenase and leukotriene biosynthesis. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1983, 753 (1), 130-132.

Chia-Yih Chu; Yu-Ying Tsai; Chau-Jong Wang; Wei-Long Lin; Tsui-Hwa Tseng. Induction of apoptosis by esculetin in human leukemia cells. European Journal of Pharmacology. 2001, 416 (1-2), 25-32.

Ultraviolet absorbent.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,3697
Beilstein
152788
Harmonized Tariff Code
2932.20
TSCA
No
RTECS
GN6382500

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