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Uracil is produced by hydrolysis of nucleic acid and used in biochemical research. It serves as a allosteric regulator and coenzyme for reactions in the human body and in plants. It reacts with fluorine to get 5-fluorouracil, which is an anticancer drug. Further, it is used in drug delivery and in pharmaceuticals. In addition to this, it is used in the synthesis of caffeine and in the determination of microbial contamination of tomatoes.
For a review of the use of uracils as starting materials in heterocyclic synthesis, see: Adv. Het. Chem., 55, 130 (1992).
Fornaro, T.; Burini, D.; Biczysko, M.; Barone, V. Hydrogen-Bonding Effects on Infrared Spectra from Anharmonic Computations: Uracil-Water Complexes and Uracil Dimers. J. Phys. Chem. A 2015, 119 (18), 4224-4236.
Cavaleiro, A. M.; Kim, S. H.; Seppala, S.; Nielsen, M. T.; Nørholm, M. H. Accurate DNA assembly and genome engineering with optimized uracil excision cloning. ACS Synth. Biol. 2015, 4 (9), 1042-1046.