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24057-28-1 - Pyridinium p-toluenesulfonate, 98+% - PPTS - Pyridinium tosylate - A15708 - Alfa Aesar

A15708 Pyridinium p-toluenesulfonate, 98+%

CAS-Nummer
24057-28-1
Synonyme
PPTS
Pyridinium tosylate

Größe Preis ($) Menge Verfügbarkeit
25g 50,00
100g 161,00
500g 675,00
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Pyridinium p-toluenesulfonate, 98+%

MDL
MFCD00013108
EINECS
246-002-7

Chemische Eigenschaften

Formel
C12H13NO3S
Molmasse
251.31
Schmelzpunkt
116-120°
Sensitivität
Moisture Sensitive
Löslichkeit
Soluble in water (partly), ethanol, acetone, dichloromethane, chloroform, methanol and dimethyl sulfoxide.

Anwendungen

Pyridinium p-Toluenesulfate is used in the synthesis of a subdomain of the cytochrome P450 BM3 enzyme, for use in screening systems for drug candidates. Efficient catalyst for preparing tetrahydropyranyl ethers.

Bemerkungen

Moisture Sensitive. Store in a tightly closed container. Store in a cool, dry, well-ventilated. Store protected from moisture.

Literaturverweise

Masaaki Miyashita; Akira Yoshikoshi; Paul A. Grieco. Pyridinium p-toluenesulfonate. A mild and efficient catalyst for the tetrahydropyranylation of alcohols. J. Org. Chem. 1977, 42 (23), 3772-3774.

Takeshi Matsukawa, Yoshihiro Mineno; Toru Odani; Shuji Okadab; Tetsuo Taniuchic;Synthesis and terahertz-wave generation of mixed crystals composed of 1-methyl-4-{2-[4-(dimethylamino)phenyl]ethenyl}pyridinium p-toluenesulfonate and p-chlorobenzenesulfonate. Journal of Crystal Growth. 2007, 299 (22), 344-348.

Mild catalyst for the formation of THP derivatives of alcohols superior to p-toluenesulfonic acid, where acid-sensitive functionality is present. Similarly, the reagent has been used for deprotection of THP ethers in ethanol: J. Org. Chem., 42. 3772 (1977).

This application has been extended to other acetalization or trans-acetalization reactions, where more acidic conditions are undesirable: Synthesis, 724 (1979).

For use in cleavage of TBDMS protecting groups, see: J. Chem. Soc. Perkin 1, 169 (1993).

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280a-P305+P351+P338-P304+P340-P312a-P321-P332+P313-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
3764305
Harmonized Tariff Code
2933.39
TSCA
Yes

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