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35386-24-4 - 1-(2-Methoxyphenyl)piperazine, 98% - A15819 - Alfa Aesar

A15819 1-(2-Methoxyphenyl)piperazine, 98%

CAS-Nummer
35386-24-4
Synonyme

Größe Preis ($) Menge Verfügbarkeit
5g 30,41
25g 104,03
100g 277,60
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1-(2-Methoxyphenyl)piperazine, 98%

MDL
MFCD00005958
EINECS
252-537-7

Chemische Eigenschaften

Formel
C11H16N2O
Molmasse
192.26
Schmelzpunkt
35-39°
Siedepunkt
130-133°/0.1mm
Flammpunkt
>110°(230°F)
Dichte
1.106
Sensitivität
Air Sensitive
Löslichkeit
Soluble in chloroform, ethyl acetate, and methanol. Insoluble in water

Anwendungen

It is used as pharmaceutical intermediate. N-alkylated 1-(2-methyoxyphenyl)piperazines markedly improved affinity and selectivity of the dopamine D3 receptor which is recognized as a potential therapeutic target for the treatment of various neurological and psychiatric disorders.

Bemerkungen

Air sensitive. Store at room temperature. Keep away from oxidizing agents.

Literaturverweise

Anneke Hackling.; Robin Ghosh.; Sylvie Perachon.; André Mann.; Hans-Dieter Höltje.; Camille G. Wermuth..; Jean-Charles Schwartz .;Wolfgang Sippl.;Pierre Sokoloff.; Holger Stark. N-(ω-(4-(2-Methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as Dopamine D2 and D3 Receptor Ligands. J. Med. Chem. 2003, 46 (18),3883-3899 .

Jerzy L. Mokrosz.; Maria H. Paluchowska.; Ewa Chojnacka-Wojcik.; Malgorzata Filip.; Sijka Charakchieva-Mino.; Anna Deren-Wesolek.; Maria J. Mokrosz. Structure-Activity Relationship Studies of Central Nervous System Agents. 13.4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a New Putative 5-HT1A Receptor Antagonist, and Its Analogs. J. Med. Chem. 1994, 37 (17), 2754-2760 .

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H301-H314-H318

Toxic if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage.

Sicherheitshinweise: P260-P280-P301+P310-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
167888
Gefahrenklasse
8
Verpackungsgruppe
III
Harmonized Tariff Code
2933.59
TSCA
No

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