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641-70-3 - 3-Nitrophthalic anhydride, 97% - A15857 - Alfa Aesar

A15857 3-Nitrophthalic anhydride, 97%

CAS-Nummer
641-70-3
Synonyme

Größe Preis ($) Menge Verfügbarkeit
25g 118,56
100g 352,98
500g 1165,60
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3-Nitrophthalic anhydride, 97%

MDL
MFCD00005921
EINECS
211-373-6

Chemische Eigenschaften

Formel
C8H3NO5
Molmasse
193.11
Schmelzpunkt
161-166°
Sensitivität
Moisture Sensitive
Löslichkeit
May decompose in water.

Anwendungen

4-Nitrophthalic Anhydride is an intermediate for the synthesis of the benzimidazole PARP inhibitor I, ABT-472. It reacts with aminoquinazolinones to yield phthalimidoquinazolinones.

Bemerkungen

Air sensitive. Store at room temperature. Keep away from oxidizing agents.

Literaturverweise

Ben H. Nicolet.; Jacob Sacks.3-Nitrophthalic Anhydride As A Reagent For Alcohols.J. Am. Chem. Soc. 1925, 47 (9),2348-2350 .

E. Wertheim. Derivatives For The Identification Of Mercaptans. J. Am. Chem. Soc. 1929, 51 (12),3661-3664 .

Has been used as an N-blocking group for amino acids in solid-phase peptide synthesis, providing an acidic 'handle' allowing separation by ion-exchange chromatography: Angew. Chem. Int. Ed., 8, 764 (1969). See Appendix 6.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
179963
Harmonized Tariff Code
2917.39
TSCA
Yes

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