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98-58-8 - 4-Bromobenzenesulfonyl chloride, 98+% - A15909 - Alfa Aesar

A15909 4-Bromobenzenesulfonyl chloride, 98+%

CAS-Nummer
98-58-8
Synonyme

Größe Preis ($) Menge Verfügbarkeit
25g 46,89
100g 117,89
500g 405,26
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

4-Bromobenzenesulfonyl chloride, 98+%

MDL
MFCD00007437
EINECS
202-683-2

Chemische Eigenschaften

Formel
C6H4BrClO2S
Molmasse
255.52
Schmelzpunkt
73-77°
Siedepunkt
152-154°/26mm
Sensitivität
Moisture Sensitive
Löslichkeit
Soluble in Tetrahydrofuran, petroleum ether and 1,4-dioxane. Insoluble in water.

Anwendungen

4-Bromobenzenesulfonyl chloride is used as activating agent in the synthesis of oligodeoxyribo- and oligoribo- nucleotides in solution. It also used in the synthesis of 4-(N-allylsulfamoyl)phenylboronic acid and in protection of amines as 4-bromobenzenesulfonamides.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive. Store under inert gas.

Literaturverweise

Reese CB.; Pei-Zhuo Z. J. Phosphotriester approach to the synthesis of oligonucleotides: a reappraisal.. Chem. Soc. Perkin Trans. I. 1993, 1 (9), 2291-2301.

Xiaobao Li.; Justin Pennington.; John F Stobaugh.; Christian Schöneich. Synthesis of sulfonamide- and sulfonyl-phenylboronic acid-modified silica phases for boronate affinity chromatography at physiological pH. Analytical Biochemistry. 2008, 372 (2), 227-236.

Used in protection of amines as 4-bromobenzenesulfonamides: Synth. Commun., 18, 1615 (1988); Tetrahedron Lett., 30, 2399 (1989).

Alcohols are converted to 4-brombenzenesulfonate ("brosylate") esters with enhanced leaving group ability relative to the commoner tosylate; see, e.g.: Carbohydr. Res., 46, 53 (1976).

In the presence of potassium carbonate and a phase-transfer catalyst, N,N'-disubstituted ureas are dehydrated to carbodiimides in high yield: Synthesis, 520 (1987).

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Sicherheitshinweise: P280-P305+P351+P338-P309-P310

Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER or doctor/physician.

Weitere Referenzen

Merck
14,1407
Beilstein
743518
Gefahrenklasse
8
Verpackungsgruppe
II
Harmonized Tariff Code
2904.90
TSCA
Yes

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