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98-92-0 - Nicotinamide, 99% - Niacinamide - Pyridine-3-carboxamide - A15970 - Alfa Aesar

A15970 Nicotinamide, 99%

CAS-Nummer
98-92-0
Synonyme
Niacinamide
Pyridine-3-carboxamide

Größe Preis ($) Menge Verfügbarkeit
100g 17,00
250g 25,90
1000g 79,70
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

Nicotinamide, 99%

MDL
MFCD00006395
EINECS
202-713-4

Chemische Eigenschaften

Formel
C6H6N2O
Molmasse
122.13
Schmelzpunkt
128-132°
Flammpunkt
182°(360°F)
Dichte
1.40
Löslichkeit
Soluble in water, ethanol , glycerol, DMSO , methanol, butanol and chloroform. Slightly soluble in ether.

Anwendungen

Nicotinamide is a building block (active component) of coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phopshate (NADP). It may be used as a substrate of nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12), the rate-limiting enzyme for NAD(+) biosynthesis and an important signaling molecule. It is an amide derivative of vitamin B3 and a PARP inhibitor.

Bemerkungen

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Literaturverweise

Kevin J.Bitterman; Rozalyn M.Anderson; Haim Y.Cohen; Magda Latorre-Esteves; David A.Sinclair. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of Yeast Sir2 and Human SIRT1. The Journal of Biological Chemistry. 2002, 277, (47),45099-45107

 

Rozalyn M.Anderson; Kevin J.Bitterman; Jason G.Wood; Oliver Medvedik; David A.Sinclair. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Letters to Nature. 2003, 423, 181-185

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H319

Causes serious eye irritation.

Sicherheitshinweise: P260u-P201-P280a-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves and eye/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,6523
Beilstein
383619
Harmonized Tariff Code
2936.29
TSCA
Yes
RTECS
QS3675000

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