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4,7-Dichloroquinoline is used as a drug chloroquine phosphate intermediate. It is also is used in the synthesis of hybrid aminoquinoline-triazine derivatives that show anti-microbial activity. In addition, it is used in the synthesis of novel oxazolidinones as anti-microbial agents showing efficacy against common bacterial strains.
Alexander R. Surrey.; Royal A. Cutler. The Role of Phenol in the Reaction of 4,7-Dichloroquinoline with Novol Diamine. J. Am. Chem. Soc. 1951, 73 (6), 2623-2626.
Robert C. Elderfield.; Walter J. Gensler.; Oskar Birstein.; Frank J. Kreysa.; John T. Maynard.; Jean Galbreath. Synthesis of Certain Simple 4-Aminoquinoline Derivatives. J. Am. Chem. Soc. 1946, 68 (7), 1250-1251.
Gefahrenhinweise (EU): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.