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Indole-3-carbonitrile is used as a synthesis reagent for preparation of 4-substituted β-lactams, biologically active indoles, inhibitors of glycogen synthase kinase 3β (GSK-3), indole fragments as inosine monophosphate dehydrogenase (IMPDH) inhibitors and HIV-1 integrase inhibitors. It is also used as a reactant for intramolecular oxidative C-H coupling reactions with applications in medium-ring synthesis techniques and for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators.
Didier G Pintori.; Michael F Greaney. Intramolecular oxidative C-H coupling for medium-ring synthesis. Journal of the American Chemical Society. 2011, 133 (5), 1209-1211.
F Y Miyake.; K Yakushijin, D A Horne. A concise synthesis of topsentin A and nortopsentins B and D. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2000, 2 (14), 2121-2123.
Gefahrenhinweise (EU): H302-H315-H319-H335
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.