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PIPES is commonly used as a buffering agent in biochemistry.
Biological buffer, pKa = 6.8 at 20o: Biochemistry, 5, 467 (1966).
Zeddies, S.; De Cuyper, I. M.; Meer, P. F.; Daal, B. B., Korte, D.; Gutiérrez, L.; Thijssen-Timmer, D. C. Pathogen reduction treatment using riboflavin and ultraviolet light impairs platelet reactivity toward specific agonists in vitro. Transfusion 2014, 54 (9), 2292-2300
Ohta, S.; Sakaguchi, S.; Kobayashi, Y.; Mizuno, N.; Tago, K.; Itoh, H. Agonistic Antibodies Reveal the Function of GPR56 in Human Glioma U87-MG Cells. Biol. Pharm. Bull. 2015, 38 (4), 594-600.