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N,N-Dimethyltrimethylsilylamine was used in the synthesis of phosphoramidite. It was also employed as a reagent in the preparation of iminium salts and amides as well as for the silylation of polymers. A combination of N-(trimethylsilyl)dimethylamine and MeI was also effective to give p-methylbenzoic acid with a 85% yield based on 90% conversion from the corresponding Me ester. DETA has been treated with N-(trimethylsilyl)-dimethylamine to yield mono-, di- and tri- silylated derivatives
Fourrey JL ,; Varenne J. A new and general procedure for the preparation of deoxynucleoside phosphoramidites.. Tetrahedron Lett. . 1983, 24 (19), 1963-1966.
Arihiro Iwata,; Joji Ohshita,; Heqing Tang,; Atsutaka Kunai. Ring-Opening Iodo- and Bromosilation of Lactones for the Formation of Silyl Haloalkanoates. J. Org. Chem. 2002, 67 (11), 3927-3929.
Reagent for siliylation of a wide range of functional groups, without the need for added base, useful for amino acids: J. Chromat. Sci., 7, 704 (1969). In the presence of the hindered ligand 2-(Di-tert-butylphosphino)biphenyl, L19758, Pd-catalyzed cross-coupling reactions with aryl halides to give substituted N,N-dimethylanilines have been effected: Chem. Commun., 1976 (2004).
Gefahrenhinweise (EU): H225-H314-H318
Highly flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage.
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