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(R)-(+)-4-Benzyl-2-oxazolidinones are used in the enantioselective synthesis of beta-lactams and alpha-amino acids. End products can include asysmmetric single isomeric drugs of antitumor, anesthetic, antipasmodic products. Used in the synthesis of HIV protease inhibitors. An oxazolidinone used in chiral auxiliary asymetric synthesis.
David J Madar,; Hana Kopecka,; Daisy Pireh,; Jonathan Pease,; Marina Pliushchev,; Richard J Sciotti,; Paul E Wiedeman,; Stevan W Djuric.Synthesis of N-arylated oxazolidinones via a palladium catalyzed cross coupling reaction. Application to the synthesis of the antibacterial agent Dup-721. Tetrahedron Letters. 2001, 42 (22),3681-3684.