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Useful reagent for trifluoroacetylation of amines under mild conditions. In the presence of 1,1,3,3-Tetramethylguanidine, has also been used for the N-acylation of amino acids. It is used as an intermediate in the synthesis of pharmaceutical and agricultural chemicals. The chemical reactions usually involve nucleophilic substitution of the ester and are useful for the preparation of trifluoroacylated compounds.
Langlois BR and Roques N. Nucleophilic trifluoromethylation of aryl halides with methyl trifluoroacetate.J. Fluor. Chem.,2007,128(10), 1318-1325.
M. N. Vargaftik, et al. Highly selective partial oxidation of methane to methyl trifluoroacetate.J. Chem. Soc., Chem. Commun.,1990,15, 1049-1050.
Useful reagent for trifluoroacetylation of amines under mild conditions. In the presence of 1,1,3,3-Tetramethylguanidine, A12314, has also been used for the N-acylation of amino acids: Synthesis, 399 (1976).
Gefahrenhinweise (EU): H225-H314-H318
Highly flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage.
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.