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431-47-0 - Methyl trifluoroacetate, 98+% - Trifluoroacetic acid methyl ester - A17338 - Alfa Aesar

A17338 Methyl trifluoroacetate, 98+%

CAS-Nummer
431-47-0
Synonyme
Trifluoroacetic acid methyl ester

Größe Preis ($) Menge Verfügbarkeit
50g 47,52
250g 235,31
1000g 837,39
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Methyl trifluoroacetate, 98+%

MDL
MFCD00000417
EINECS
207-074-5

Chemische Eigenschaften

Formel
CF3CO2CH3
Molmasse
128.05
Schmelzpunkt
-78°
Siedepunkt
43-44°
Flammpunkt
-18°(-0.4°F)
Dichte
1.283
Brechungsindex
1.2900
Sensitivität
Moisture Sensitive
Löslichkeit
Not miscible or difficult to mix in water.

Anwendungen

Useful reagent for trifluoroacetylation of amines under mild conditions. In the presence of 1,1,3,3-Tetramethyl­guanidine, has also been used for the N-acylation of amino acids. It is used as an intermediate in the synthesis of pharmaceutical and agricultural chemicals. The chemical reactions usually involve nucleophilic substitution of the ester and are useful for the preparation of trifluoroacylated compounds.

Bemerkungen

Moisture sensitive. Store away from strong bases, water/moisture and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Protect from humidity.

Literaturverweise

Langlois BR and Roques N. Nucleophilic trifluoromethylation of aryl halides with methyl trifluoroacetate.J. Fluor. Chem.,2007,128(10), 1318-1325.

M. N. Vargaftik, et al. Highly selective partial oxidation of methane to methyl trifluoroacetate.J. Chem. Soc., Chem. Commun.,1990,15, 1049-1050.

Useful reagent for trifluoroacetylation of amines under mild conditions. In the presence of 1,1,3,3-Tetramethyl­guanidine, A12314, has also been used for the N-acylation of amino acids: Synthesis, 399 (1976).

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H225-H314-H318

Highly flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage.

Sicherheitshinweise: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
1756070
Gefahrenklasse
3
Verpackungsgruppe
II
Harmonized Tariff Code
2915.90
TSCA
Yes

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