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117-08-8 - Tetrachlorophthalic anhydride, 98% - A17404 - Alfa Aesar

A17404 Tetrachlorophthalic anhydride, 98%

CAS-Nummer
117-08-8
Synonyme

Größe Preis ($) Menge Verfügbarkeit
500g 36,05
2500g 112,50
10000g 432,60
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Tetrachlorophthalic anhydride, 98%

MDL
MFCD00005920
EINECS
204-171-4

Chemische Eigenschaften

Formel
C8Cl4O3
Molmasse
285.90
Schmelzpunkt
254-258°
Siedepunkt
349-354°
Flammpunkt
362°(683°F)
Sensitivität
Moisture Sensitive
Löslichkeit
Hydrolyzes slowly in water.

Anwendungen

Protection of amines as their tetrachlorophthalimide derivatives, by reaction with the anhydride in the presence of triethylamine, has been found to be useful in oligosaccharide chemistry. The group is stable to a wide range of reagents but can be selectively cleaved with ethylenediamine at lower temperatures than for the parent phthalimide derivatives; in particular, carboxylic esters are not cleaved under these conditions.

Bemerkungen

Hygroscopic. Store away from oxidizing agents, acids.

Literaturverweise

Wilfred Howe, A.F.O.M., M.R.C.G.P.; Katherine M. Venables, M.Sc., M.R.C.P.; Michael D. Topping, Ph.D.; Michael B. Dally, M.R.A.C.P.; Rosemarie Hawkins, S.R.N.; J.Stephen Law, M.D.; Anthony J.Newman Taylor, M.Sc., M.R.C.P. Tetrachlorophthalic anhydride asthma: evidence for specific IgE antibody Journal of Allergy and Clinical Immunology. 1983, 71 (1), 5-11.

Gary M. Liss, MD, MS, FRCPC.; David Bernstein, MD.; Leon Genesove, MD, FRCPC.; Jaan O. Roos, MD, FRCPC.; Janet Lim, MD. Assessment of risk factors for IgE-mediated sensitization to tetrachlorophthalic anhydride. Journal of Allergy and Clinical Immunology. 1993, 92 ( 237-247),.

Protection of amines as their tetrachlorophthalimide derivatives, by reaction with the anhydride in the presence of triethylamine, has been found to be useful in oligosaccharide chemistry. The group is stable to a wide range of reagents but can be selectively cleaved with ethylenediamine at lower temperatures than for the parent phthalimide derivatives; in particular, carboxylic esters are not cleaved under these conditions: J. Am. Chem. Soc., 117, 3302 (1995); J. Org. Chem., 61, 432 (1996).

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H334-H317-H318-H400-H410

May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction. Causes serious eye damage. Very toxic to aquatic life. Very toxic to aquatic life with long lasting effects.

Sicherheitshinweise: P285-P261-P273-P280-P305+P351+P338-P310-P342+P311-P363-P304+P341-P501a

In case of inadequate ventilation wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. IF INHALED: If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
211560
Gefahrenklasse
9
Verpackungsgruppe
III
Harmonized Tariff Code
2917.39
TSCA
Yes
RTECS
TI3450000

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