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3376-24-7 - N-tert-Butyl-alpha-phenylnitrone, 98% - PBN - alpha-Phenyl-N-tert-butylnitrone - A17442 - Alfa Aesar

A17442 N-tert-Butyl-alpha-phenylnitrone, 98%

CAS-Nummer
3376-24-7
Synonyme
PBN
alpha-Phenyl-N-tert-butylnitrone

Größe Preis ($) Menge Verfügbarkeit
1g 50,88
5g 178,20
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N-tert-Butyl-alpha-phenylnitrone, 98%

MDL
MFCD00008799
EINECS
222-168-6

Chemische Eigenschaften

Formel
C11H15NO
Molmasse
177.25
Schmelzpunkt
71-75°
Löslichkeit
Soluble in DMSO (10 mg/ml), chloroform (50 mg/ml), and water (20 mg/ml).

Anwendungen

N-tert-Butyl-a-phenylnitrone is a commonly-used free radical trap. It contains radical scavenging activity and an ability to inhibit Cox-2 (cyclooxygenase-2). N-tert-Butyl-a-phenylnitrone is an antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. N-tert-Butyl-a-phenylnitrone inhibits lipid peroxidation in rat liver microsomes. It also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.

Bemerkungen

Store in a cool place. Reactive with oxidizing agents.

Literaturverweise

Edward G. Janzen.; C. Anderson Evans. Rate constants for the addition of phenyl radicals to N-(tert-butyl)-.alpha.-phenylnitrone (spin trapping) and benzene (phenylation) as studied by electron spin resonance. J. Am. Chem. Soc. 1975, 97 (1), 205-206.

Xianghui Cao.; John W. Phillis. α-Phenyl-tert-butyl-nitrone reduces cortical infarct and edema in rats subjected to focal ischemia. Brain Research. 1994, 644 (2), 267-272.

For examples of 1,3-dipolar cycloaddition reactions, see N,ɑ-Diphenyl­ nitrone, L00185.

Weitere Referenzen

Merck
14,7056
Beilstein
2044028
Harmonized Tariff Code
2929.90
TSCA
Yes

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