A17871 2,2,2-Trifluoroethyl p-toluenesulfonate, 98+%
SDS
| Stock No. | Größe | Preis ($) | Menge | Verfügbarkeit |
|---|---|---|---|---|
| A17871-14 | 25g | 31,70 |
|
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| A17871-22 | 100g | 109,00 |
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2,2,2-Trifluoroethyl p-toluenesulfonate, 98+%
Chemische Eigenschaften
Literaturverweise
Alkylating agent for introduction of the trifluoroethyl group.
/nMetallation by LDA leads to 2,2-difluoro-1-tosyloxyvinyllithium, which adds quantitatively to carbonyl groups. Acid hydrolysis leads to ɑ-tosyloxy acrylates, which can be hydrolyzed to ɑ-keto acids by base: Tetrahedron Lett., 4809 (1978):
/n
n-BuLi at -78o has also been used by Ichikawa's group to generate the vinyllithium intermediate, which undergoes boron or copper mediated reactions yielding 2,2-difluorovinyl ketones and other products. See, e.g.: Tetrahedron Lett., 33, 337 (1992); Tetrahedron, 50, 11637 (1994); J. Org. Chem., 60, 2320 (1995).
/nGHS Gefahren- und Sicherheitshinweise
Gefahrenhinweise (EU): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Sicherheitshinweise: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.
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