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Used for preparation of anhydrous Li salts of carboxylic acids prior to reaction with organothium reagents (most often methyl or phenyl) as a useful route to ketones. Also used in the preparation of LiCN by reaction with acetone cyanohydrins. It is also applied as a desiccating and condensing agent and a shielding material in nuclear energy production. It is used in the manufacture of catalysts for polyolefin plastics; in fuels for aircraft, missiles. It is used in metallurgy, as degasifier, deoxidizer, desulfurizer; as grain refiner in non-ferrous metals. Employed as a chemical intermediate for butyllithium polymerization catalyst; in alloys with aluminum or magnesium for aerospace uses.
Takeshi Ohkuma.; Shohei Hashiguchi.; Ryoji Noyori. A practical method for activation of commercial lithium hydride: reductive silylation of carbonyl compounds with lithium hydride and chlorotrimethylsilane.J. Org. Chem.,1994,59(1), 217-221.
F.E. Pretzel.; G.N. Rupert.; C.L. Mader.; E.K. Storms.; G.V. Gritton.; C.C. Rushing. Properties of lithium hydride I. Single crystals.J. Phys. Chem. Solids.,1960,16(1-2), 10-20.
Used for preparation of anhydrous Li salts of carboxylic acids prior to reaction with organothium reagents (most often methyl or phenyl) as a useful route to ketones. For a comprehensive review of this method, see: Org. React., 18, 1 (1970). For an example (cyclohexyl methyl ketone), see: Org. Synth. Coll., 5, 775 (1973).
For preparation of LiCN by reaction with acetone cyanohydrin, see: Org. Synth. Coll., 7, 517 (1990).
A procedure for activation involves treatment with TMS chloride and a catalytic amount of Zn or a Zn salt. This reagent will reduce a ketone to the TMS ether of the alcohol: J. Org. Chem., 59, 217 (1994).
Gefahrenhinweise (EU): H260-H314-H318
In contact with water releases flammable gases which may ignite spontaneously. Causes severe skin burns and eye damage. Causes serious eye damage.
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Handle under inert gas. Protect from moisture. Do not get in eyes, on skin, or on clothing. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: