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22381-54-0 - 2-(p-Toluenesulfonyl)ethanol, 98% - 2-(4-Methylphenylsulfonyl)ethanol - 2-(p-Tosyl)ethanol - A18249 - Alfa Aesar

A18249 2-(p-Toluenesulfonyl)ethanol, 98%

CAS-Nummer
22381-54-0
Synonyme
2-(4-Methylphenylsulfonyl)ethanol
2-(p-Tosyl)ethanol

2-(p-Toluenesulfonyl)ethanol, 98%

MDL
MFCD00041757

Chemische Eigenschaften

Formel
C9H12O3S
Molmasse
200.26
Schmelzpunkt
50-53°
Siedepunkt
178-181°/0.2mm
Löslichkeit
Slightly soluble in water.

Anwendungen

2-(p-Toluenesulfonyl)ethanol is used as an organic chemical synthesis intermediate.

Bemerkungen

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Literaturverweise

Emanuel H.F.Escher; Helene Robert; Domenico C.Regoli; Serge A.St. Pierre. Photoaffinity labeling of the angiotensin II receptor. 1. Synthesis and biological activities of the labeling peptides. J. Med. Chem. 1978, 21,(9), 860-864.

 

Reagent for protection of the carboxyl group as its 2-(p-toluenesulfonyl)ethyl (Tse) [2-(4-methylphenylsulfonyl)ethyl (Mpse)] ester, e.g. by DCC coupling. The Tse group is useful for carboxyl protection of Boc amino acids in peptide synthesis, since it is stable to the acidic conditions used for Boc cleavage, but readily cleaved by mild base, e.g. dilute NaOH or Na2CO3 in dioxan-water: J. Chem. Soc.(C)., 2612 (1968). It can also be cleaved by non-aqueous bases, e.g. DBN: J. Chem. Soc., Chem. Commun., 1031 (1972), DBU: Tetrahedron Lett., 25, 2163 (1984), or TBAF in THF: Chem. Lett., 1595 (1987).

Weitere Referenzen

Beilstein
1961132
Harmonized Tariff Code
2930.90
TSCA
Yes

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