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2,3,5,6-Tetramethylpyrazine is an anti-inflammatory compound isolated from the fermented food natto. It demonstrated in vivo nootropic activity in rats. It is useful in the treatment of several disorders such as asthma, heart failure, rhinitis and urinary incontinence. It is a flavor ingredient of tobacco. It forms cocrystal with 4-hydroxybenzoic acid which exhibits supramolecular synthon polymorphism.
B.R.Sreekanth; Peddy Vishweshwar; K.Vyas. Supramolecular synthon polymorphism in 2 : 1 co-crystal of 4-hydroxybenzoic acid and 2,3,5,6-tetramethylpyrazine. Chemical Communications. 2007, 23,2375-2377.
Wei Wu; Xiao Yu; Xiao-Ping Luo; Shu-Hua Yang; Dong Zheng. Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway. Behavioural Brain Research. 2013, 253,212-216.
Has been used as a component of a buffer to control the acid-catalyzed ring-opening of epoxides: J. Chem. Soc., Perkin 2, 1309 (1972).
Gefahrenhinweise (EU): H301-H315-H319-H335
Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.