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52186-89-7 - (1-Ethoxycarbonylcyclopropyl)triphenylphosphonium tetrafluoroborate, 98% - (1-Carboethoxycyclopropyl)triphenylphosphonium tetrafluoroborate - Fuchs' Reagent - A18305 - Alfa Aesar

A18305 (1-Ethoxycarbonylcyclopropyl)triphenylphosphonium tetrafluoroborate, 98%

CAS-Nummer
52186-89-7
Synonyme
(1-Carboethoxycyclopropyl)triphenylphosphonium tetrafluoroborate
Fuchs' Reagent

Größe Preis ($) Menge Verfügbarkeit
1g 23,84
5g 123,60
25g 399,20
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(1-Ethoxycarbonylcyclopropyl)triphenylphosphonium tetrafluoroborate, 98%

MDL
MFCD00051879

Chemische Eigenschaften

Formel
C24H24BF4O2P
Molmasse
462.23
Schmelzpunkt
173-179°
Löslichkeit
Slightly soluble in water.

Anwendungen

(1-Ethoxycarbonylcyclopropyl)triphenylphosphonium tetrafluoroborate is used as pharmaceutical intermediate.

Bemerkungen

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Literaturverweise

Seung Won Chung; Mark S.Plummer; Laura A.McAllister; Robert M.OliverIII; Joseph A.Abramite; Yue Shen; Jianmin Sun; Daniel P.Uccello; Joel T.Arcari; Loren M.Price; Justin I.Montgomery. Org. Lett. 2011, 13,(19), 5338-5341.

 

Valuable intermediate for cycloalkenylation of compounds containing a nucleophilic center and a carbonyl group. Nucleophilic ring-opening of the cyclopropyl ring is followed by intramolecular Wittig reaction (see Appendix 1) of the intermediate carbonyl-phosphorane; e.g., with ß-keto esters, cyclopentenes are formed: J. Am. Chem. Soc., 96, 1607 (1974):

With 2-formylcyclohexanones, spirocyclopentenes are obtained: J. Am. Chem. Soc., 99, 7307 (1977). Na carboxylates give 2,3-dihydrofurans: Tetrahedron Lett., 4353 (1975), and thiolcarboxylates give dihydrothiophenes, readily aromatized to thiophenes with DDQ: J. Chem. Soc., Perkin 1, 2403 (1994):

Cyclic imides e.g. Succinimide, A13503, give bridgehead lactams: Liebigs Ann. Chem., 521 (1983); for reaction scheme, see Glutarimide, L00968.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
4650673
Harmonized Tariff Code
2931.90
TSCA
No

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