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75-80-9 - 2,2,2-Tribromoethanol, 99% - 2,2,2-Tribromoethyl alcohol - A18706 - Alfa Aesar

A18706 2,2,2-Tribromoethanol, 99%

CAS-Nummer
75-80-9
Synonyme
2,2,2-Tribromoethyl alcohol

Größe Preis ($) Menge Verfügbarkeit
5g 26,50
25g 77,20
100g 233,00
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

2,2,2-Tribromoethanol, 99%

MDL
MFCD00004671
EINECS
200-903-1

Chemische Eigenschaften

Formel
Br3CCH2OH
Molmasse
282.76
Schmelzpunkt
77-80°
Siedepunkt
92-93°/10mm
Sensitivität
Light Sensitive
Löslichkeit
Soluble in alcohol, ether, benzene and warmpetroleum ether. Partially soluble in water.

Anwendungen

2,2,2-Tribromoethanol is utilized in organic synthesis of beta-amino alcohols. The pharmaceutical preparation of tribromoethanol serves as an anesthetic in medicine.

Bemerkungen

Light Sensitive. Store in cool and well ventilated area. Keep container tightly closed.

Literaturverweise

Carboxyl groups can be protected as tribromoethyl esters, e.g. by reaction of the acid chloride in the presence of N,N-dimethylaniline. The group is readily cleaved with Zn/AcOH: J. Chem. Soc., Pekin 1., 2875 (1993); (cf. 2,2,2-Trichloroethanol, L08163). The group has also been exploited in the activation of carboxylic acids for amidation with amines, by reductive cleavage of the tribromoethyl ester with a P(III) reagent, preferably Hexamethyl­phosphorous triamide, A12571, and triethylamine. In an analogous esterification method with alcohols, tributylphosphine - DMAP was the preferred system: J. Org. Chem., 64, 1430 (1999).

Maheras, K. J.; Gow, A. Increased anesthesia time using 2,2,2-tribromoethanol-chloral hydrate with low impact on mouse psychoacoustics. J. Am. Assoc. Lab. Anim. Sci. 2002, 41 (3), 28-32.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
1733249
Harmonized Tariff Code
2905.59
TSCA
Yes
RTECS
KM3675000

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