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7693-46-1 - 4-Nitrophenyl chloroformate, 97% - Chloroformic acid 4-nitrophenyl ester - A18742 - Alfa Aesar

A18742 4-Nitrophenyl chloroformate, 97%

CAS-Nummer
7693-46-1
Synonyme
Chloroformic acid 4-nitrophenyl ester

Größe Preis ($) Menge Verfügbarkeit
5g 32,30
25g 88,80
100g 258,00
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

4-Nitrophenyl chloroformate, 97%

MDL
MFCD00007321
EINECS
231-706-9

Chemische Eigenschaften

Formel
C7H4ClNO4
Molmasse
201.57
Schmelzpunkt
75-82°
Siedepunkt
159-162°/19mm
Flammpunkt
>110°(230°F)
Sensitivität
Moisture Sensitive
Löslichkeit
Soluble in acetone, chloroform, acetone, toluene and benzene.

Anwendungen

4-Nitrophenyl chloroformate is used in the synthesis of poly(oxyethylene) modified dextrans. It is also used to prepare a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA. Further, it is used in the synthesis of mixed, activated carbonates, thiocarbonates and activated urethanes. In addition to this, it is used in the preparation of 4-nitrophenyl diazoacetate with diazomethane.

Bemerkungen

Moisture sensitive. Store in a cool place. Incompatible with water, acids, alcohols, ammonia, amines and strong bases.

Literaturverweise

Reagent for protection of nucleoside alcohols. The carbonate derivatives readily undergo aqueous hydrolysis in the presence of imidazole: J. Org. Chem., 33, 3699 (1967). For use in the formation of a carbonate linker in an efficient N-terminal attachment methodology for solid phase peptide synthesis, see: Synlett, 1609 (2000).

Sarma, B. K.; Liu, X.; Wu, H.; Gao, Y.; Kodadek, T. Solid phase synthesis of 1,3,4-oxadiazin-5 (6R)-one and 1,3,4-oxadiazol-2-one scaffolds from acyl hydrazides. Org. Biomol. Chem. 2015, 13 (1), 59-63.

Lee, N. R.; Zhang, X.; Darna, M.; Dwoskin, L. P.; Zheng, G. Muscarinic acetylcholine receptor binding affinities of pethidine analogs. Bioorg. Med. Chem. Lett. 2015, 25 (22), 5032-5035.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H302-H314-H318-H335

Harmful if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage. May cause respiratory irritation.

Sicherheitshinweise: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
518127
Gefahrenklasse
8
Verpackungsgruppe
II
Harmonized Tariff Code
2915.90
TSCA
Yes

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