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124-20-9 - Spermidine, 99% - N-(3-Aminopropyl)-1,4-diaminobutane - 1,8-Diamino-4-azaoctane - A19096 - Alfa Aesar

A19096 Spermidine, 99%

CAS-Nummer
124-20-9
Synonyme
N-(3-Aminopropyl)-1,4-diaminobutane
1,8-Diamino-4-azaoctane

Größe Preis ($) Menge Verfügbarkeit
1g 26,16
5g 77,25
25g 259,20
100g 671,56
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Spermidine, 99%

MDL
MFCD00008229
EINECS
204-689-0

Chemische Eigenschaften

Formel
H2N(CH2)3NH(CH2)4NH2
Molmasse
145.25
Schmelzpunkt
22-25°
Siedepunkt
128-130°/14mm
Flammpunkt
>110°(230°F)
Dichte
0.925
Brechungsindex
1.4790
Sensitivität
Air Sensitive
Löslichkeit
Miscible with water, ethanol and ether.

Anwendungen

Binds to the polyamine modulatory site of NMDA Spermidine is used in electroporation during transferring the DNA into the cell under the electrical impulse. It is also used for purification of DNA-binding proteins. It combines with calcium chloride and utilized for the precipitation of DNA onto microprojectiles for bombardment with a gene gun. It plays an important role to reduce the amount of aging in yeast, flies, worms, and human immune cells by inducing autophagy. It serves as a precursor of spermine and essential for both normal and neoplastic tissue growth.

Bemerkungen

Hygroscopic. Incompatible with acids, acid chlorides, acid anhydrides and oxidizing agents.

Literaturverweise

Pietrocola, F.; Lachkar, S.; Enot, D. P.; Niso-Santano, M.; Bravo-San Pedro, J. M.; Sica, V.; Izzo, V.; Maiuri, M C.; Madeo, F.; Mariño, G.; Kroemer, G. Spermidine induces autophagy by inhibiting the acetyltransferase EP300. Cell Death Differ. 2015, 22 (3), 509-516.

Ibarra, A. A. G.; Wrobel, K.; Escobosa, A. R. C.; Elguera, J. C. T.; Garay-Sevilla, M. E.; Wrobel, K. Determination of putrescine, cadaverine, spermidine and spermine in different chemical matrices by high performance liquid chromatography-electrospray ionization-ion trap tandem mass spectrometry (HPLC-ESI-ITMS/MS). J. Chromatogr. B 2015, 1002, 176-184.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Sicherheitshinweise: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,8742
Beilstein
1698591
Gefahrenklasse
8
Verpackungsgruppe
III
Harmonized Tariff Code
2921.29
TSCA
Yes
RTECS
EJ7000000

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