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(+)-Nootkatone, crystalline is used as an effective repellent in mosquitos, bed bugs, lone star ticks and head lice. It is also used as a food additive and flavoring material in beverages. It finds application in fragrances, cosmetics and pharmaceuticals. Further, it is used as a flavor material in beverage, frozen dairy and baked good applications.
Schulz, S.; Girhard, M.; Gaßmeyer, S. K.; Jäger, V. D.; Schwarze, D.; Vogel, A.; Urlacher, V. B. Selective Enzymatic Synthesis of the Grapefruit Flavor (+)-Nootkatone. ChemCatChem 2015, 7 (4), 601-604.
Omarini, A. B.; Plagemann, I.; Schimanski, S.; Krings, U.; Berger, R. G. Crosses between monokaryons of Pleurotus sapidus or Pleurotus florida show an improved biotransformation of (+)-valencene to (+)-nootkatone. Bioresour. Technol. 2014, 171, 113-119.