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D-(+)-Trehalose dihydrate is used as a food additive in many processed foods and pharmaceutical excipients. It is widely used as a direct replacement of conventional sweeteners and protects the cells from various environmental stresses. It finds application in the treatment of Huntington's disease and Parkinson's disease.
Schultz, I.; Vollmers, F.; Luhmann, T.; Rybak, J. C.; Wittmann, R.; Stank, K.; Steckel, H.; Kardziev, B.; Schmidt, M.; Hogger, P.; Meinel, L. Pulmonary Insulin-like Growth Factor I Delivery from Trehalose and Silk-Fibroin Microparticles. ACS Biomater. Sci. Eng. 2015, 1 (2), 119-129.
Amaro, M. I.; Tajber, L.; Corrigan, O. I.; Healy, A. M. Co-Spray Dried Carbohydrate Microparticles: Crystallisation Delay/Inhibition and Improved Aerosolization Characteristics Through the Incorporation of Hydroxypropyl-beta-cyclodextrin with Amorphous Raffinose or Trehalose. Pharm. Res. 2015, 32 (1), 180-195.
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