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It is a non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. It finds its application as gout suppressant, non-steroidal anti-inflammatory drug and analgesic. It also plays many biological roles. Additionally, Indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis.
Tinny T.; Chacko AJ.; Jose S. Formulation development and statistical optimization of chronotherapeutic tablets of indometacin.Drug Dev. Ind. Pharm.2013,39(9), 1357-1363.
Han L, et al. Indometacin ameliorates high glucose-induced proliferation and invasion via modulation of e-cadherin in pancreatic cancer cells. Current medicinal chemistry.2013,20(33), 4142-4152.
Gefahrenhinweise (EU): H300-H341
Fatal if swallowed. Suspected of causing genetic defects.
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