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2,3-Dimethylanisole is used as starting reagent in the synthesis of biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2. It can be used to produce 2-methoxy-6-methyl-benzaldehyde by heating.
Goldberg Y, et al. Highly regioselective bromination of 2, 3-dimethylanisole with N-bromosuccinimide.J. Org. Chem.1992,57(23), 6374-6376.
Ruggero Galici, et al. Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice.J Pharmacol Exp Ther.2006,318(1),173-185.
Methyl groups o- or p- to alkoxy groups can be selectively oxidized to the aldehyde by potassium peroxydisulfate in the presence of Cu(II): Synthesis, 723 (1987).
Gefahrenhinweise (EU): H227
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