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57-66-9 - Probenecid, 98% - 4-(Di-n-propylaminosulfonyl)benzoic acid - 4-(Di-n-propylsulfamoyl)benzoic acid - B20010 - Alfa Aesar

B20010 Probenecid, 98%

CAS-Nummer
57-66-9
Synonyme
4-(Di-n-propylaminosulfonyl)benzoic acid
4-(Di-n-propylsulfamoyl)benzoic acid

Größe Preis ($) Menge Verfügbarkeit
2.5g 50,22
10g 135,90
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Probenecid, 98%

MDL
MFCD00038402
EINECS
200-344-3

Chemische Eigenschaften

Formel
C13H19NO4S
Molmasse
285.36
Schmelzpunkt
198-199°
Löslichkeit
Soluble in water (partly miscible), solutions of alkali hydroxides,, ethanol (100 mM), acetone, chloroform, sodium hydroxide (1 M), DMSO (100 mM), methanol, dilute acids (practically insoluble), dilute alkalies, and ether (slightly soluble).

Anwendungen

It is a uricosuric drug, that is, it increases uric acid excretion in the urine. It is primarily used in treating gout and hyperuricemia. Probenecid was developed as an alternative to caronamide to competitively inhibit renal excretion of some drugs, thereby increasing their plasma concentration and prolonging their effects.

Bemerkungen

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literaturverweise

Campos-Arroyo D, et al. Probenecid is a chemosensitizer in cancer cell lines.Cancer chemotherapy and pharmacology.1992,69(2), 495-504.

Robbins N, et al. The history and future of probenecid.Cardiovascular toxicology.2012,12(1), 1-9.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H301-H315-H319-H335

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280-P301+P310-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,7754
Harmonized Tariff Code
2935.00
TSCA
Yes
RTECS
DG9400000

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